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Clinical and Case Studies for Biolife's Proprietary Powder
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Comparison of a Novel Hemostatic Agent to Currently Available Agents in a Swine Model of Lethal
Arterial Extremity Hemorrhage, University of Michigan Study – Susan Stern et al.
PRO QR Powder is proven to stop severe hemorrhage in only four minutes in a swine study of a lethal arterial femoral 6mm
punch biopsy. PRO QR significantly reduced mortality, hemorrhage volume, and resuscitation requirements as compared
to all other tested agents.

Comparative Evaluation of Noninvasive Compression Adjuncts for Hemostasis in Percutaneous
Arterial, Venous, and Arteriovenous Dialysis Access Procedures, Journal of Vascular and
Interventional Radiology, January 2008; 19: 72-79. Michael D. Kuo, MD et al.
PRO QR Powder is proven to achieve hemostasis in less than two minutes for venous access and four minutes for arterial
procedures based on results from a randomized controlled clinical study.

Clinical Study in an Emergency Setting, David Letts, MD
Evaluation of PRO QR Powder as a wound care agent to stop bleeding of minor wounds showed a 96% success rate. In
70% of cases, bleeding stopped in 15 seconds or less.

PRO QR Product Trial for PICC Lines
In a product trial of PRO QR Powder on 418 PICC lines at a large Florida hospital. Time to Hemostasis (TTH) needed to
control bleeding and exudates was less than or equal to 2 minutes in 94% of applications, the 48 hour dressing change
was eliminated in all cases, there were no adverse events reported, and there was a 40% decrease in Catheter-related
Bloodstream Infections (CRBSIs).

Novel Management of Wound Dehiscence: Case Study, The American Journal of Cosmetic Surgery,
Vol. 25, 3: 152-156. David N. Michelson, MD

Treating A Bleeding Deep Tissue Injury (DTI) with PRO QR Powder - A Case Study,
Kathy Gibson, MSN, RN, APBC, CWOCN
PRO QR Powder effectively stopped the bleeding from a heel wound with no side effects as compared to other potential
treatments such as cauterization. Considerable improvement in DTI healing was visible within 9 days. For this patient, the
use of PRO QR powder saved nursing time, enhanced healing, and facilitated discharge to the appropriate level of care.

Treating a Diabetic Heel Ulcer Post-Debridement With PRO QR Powder - A Case Study,
Kathy Gibson, MSN, RN, APBC, CWOCN
PRO QR Powder effectively stopped the bleeding from the heel wound. PRO QR powder was easy to use and more cost-
effective than other more expensive hemostatic agents. Additionally, since advanced wound therapy could begin, the patient
was happy to be discharged home at the next dressing change minimizing length of stay.

Hydrophilic Polymers with Potassium Salt and Microporous Polysaccharides for Use as Hemostatic
Agents, Julia Ho, MD A review of hemostatic agents as adjuncts to hemostasis indicates that hydrophilic polymers with
potassium salts (PRO QR/QR Powder) can be an effective adjunct to hemostasis after cautery and ligation and can lead to
decreased office visits.

Hospice Case Study, Douglas Rogers, DO
When cauterization was not effective in achieving hemostasis, QR Powder effectively stopped the bleeding from external
tumors on the anterior chest wall of a hospice patient diagnosed with melanoma.

PRO QR to Control Oozing from a Temporary Dialysis Catheter – A Case Study
When a leukemia patient with a 12 Fr dual lumen temporary dialysis catheter suffered oozing around the catheter to the
point that a large clot formed, Pro QR Powder proved highly effective in maintaining hemostasis and protecting the access
site.

Other clinical references, testimonials and case information available as needed for Dermatology,
Wound Care, and other applications. Please contact Biolife, LLC at 1-800-722-7559 for copies of
these studies or for more information.

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