BioSeal CVC Powder: Proven Efficacy Through
Clinical and Laboratory Studies
Forms an Effective Microbial Barrier Around Catheters
This study was featured in a national podium presentation at AVA (Association
for Vascular Access) September, 2009
Clinical and Laboratory Studies
Forms an Effective Microbial Barrier Around Catheters
This study was featured in a national podium presentation at AVA (Association
for Vascular Access) September, 2009
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A 39-day trial* of BioSeal CVC Powder (formerly PRO QR) for all PICC insertions
(418) and occasional bleeding during dressing changes or line discontinuations
at a large Florida hospital showed:
• Time to Hemostasis (TTH) was <= 2 min. in 94% of applications
• TTH for patients with clotting difficulties was <= 2 min. in 96% of applications
• The 48-hour dressing change was eliminated; initial dressing change
performed at 7 days
• No reported complications
(418) and occasional bleeding during dressing changes or line discontinuations
at a large Florida hospital showed:
• Time to Hemostasis (TTH) was <= 2 min. in 94% of applications
• TTH for patients with clotting difficulties was <= 2 min. in 96% of applications
• The 48-hour dressing change was eliminated; initial dressing change
performed at 7 days
• No reported complications
Post-hoc review showed a 40% decrease in Catheter-Related Bloodstream Infections
(CRBSIs) during and post trial.
* Study report on file with Biolife, LLC
(CRBSIs) during and post trial.
* Study report on file with Biolife, LLC
Creates a Hostile Environment for Microbes
In-Vitro studies** show that the “BioSeal”:
• Creates a hostile environment against colonizing microbes in in-vitro testing. On
the distal side of the seal, pH is low, ~2, while on the proximal side of the seal,
pH is neutral.
• Kills common microbes – S. aureus, E. coli, P. aeruginosa, C. albicans, MRSA,
MRSE and VRE for 7 days with a daily rechallenge.
** Study report on file with Biolife, LLC
In-Vitro studies** show that the “BioSeal”:
• Creates a hostile environment against colonizing microbes in in-vitro testing. On
the distal side of the seal, pH is low, ~2, while on the proximal side of the seal,
pH is neutral.
• Kills common microbes – S. aureus, E. coli, P. aeruginosa, C. albicans, MRSA,
MRSE and VRE for 7 days with a daily rechallenge.
** Study report on file with Biolife, LLC
Achieves Rapid Hemostasis for Vascular Access
Procedures
In a peer-reviewed clinical trial† comparing the efficacy of two compression adjuncts in
176 percutaneous vascular access procedures, BioSeal CVC Powder (formerly PRO QR)
was twice as fast in achieving hemostasis as the control with no differences in infections
or adverse events.
Procedures
In a peer-reviewed clinical trial† comparing the efficacy of two compression adjuncts in
176 percutaneous vascular access procedures, BioSeal CVC Powder (formerly PRO QR)
was twice as fast in achieving hemostasis as the control with no differences in infections
or adverse events.
†Wang DS, Chu LF, Olson SE, Miller FJ, Valji K, Wong WH, Rose SC, Austin M, Kuo MD. Comparative Evaluation of Noninvasive
Compression Adjuncts for Hemostasis in Percutaneous Arterial, Venous, and Arteriovenous Dialysis Access Procedures. Journal
of Vascular and Interventional Radiology January 2008; 19: 72-79.
Compression Adjuncts for Hemostasis in Percutaneous Arterial, Venous, and Arteriovenous Dialysis Access Procedures. Journal
of Vascular and Interventional Radiology January 2008; 19: 72-79.
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